diff --git a/script/include/run_setup b/script/include/run_setup
index 97fa0808..fd026477 100755
--- a/script/include/run_setup
+++ b/script/include/run_setup
@@ -1,5 +1,5 @@
-# include/setup: Set up application for the first time after cloning, or set it
-#                back to the initial first unused state.
+# setup: Set up application for the first time after cloning, or set it
+#        back to the initial first unused state.
 
 # Load setup functions
 source ./script/include/setup_functions.inc.sh
@@ -16,6 +16,9 @@ if [ -z "${INSTALL_SASS+is_set}" ]; then
 fi
 
 ## Main
+# Remove any existing node modules as part of initial app setup or reset
+rm -rf ./node_modules
+
 if [ "${CREATE_VENV}" = "true" ]; then
   install_pipenv
   create_virtual_environment